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Early research Level C · preliminary human evidence

Spermidine

Autophagy

Mechanism

A polyamine studied for its relationship with autophagy, the cell's internal recycling.

Research summary

There are laboratory data, observations in populations, and human trials that are still small.

Human evidence

This is early research. It is not proof of more years of life.

Safety

This is not a treatment. Anyone who is pregnant, nursing, underage, or taking medication should consult a professional before using a supplement. Some sources are derived from wheat.

References

1. Hallmarks of aging: An expanding universeLópez-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Cell, 2023.DOI 10.1016/j.cell.2022.11.001Updates the framework to twelve hallmarks, including chronic inflammation and dysbiosis. It does not show that human aging can be slowed.

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