Explorer

Promising Level C · preliminary human evidence

NAD+

Cellular energy

Mechanism

A cofactor of redox reactions and a substrate of signaling enzymes. It is not, by itself, a product of this site.

Research summary

NAD+ biochemistry is well described. Its decline with age, and the effect of restoring it, are studied mostly in the laboratory and in animals.

Human evidence

In people, the open question is whether raising NAD+ changes health outcomes that matter. There is no proof today that it lengthens human life.

Safety

This is not a treatment. Anyone who is pregnant, nursing, underage, or taking medication should consult a professional before using a supplement.

References

1. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo EvidenceRajman L, Chwalek K, Sinclair DA. Cell Metabolism, 2018.DOI 10.1016/j.cmet.2018.02.011Reviews the role of NAD+ and of molecules that raise it. The lifespan extension it cites comes mostly from animal models.
2. NAD+ and sirtuins in aging and diseaseImai S, Guarente L. Trends in Cell Biology, 2014.DOI 10.1016/j.tcb.2014.04.002Describes NAD+ and sirtuins as an axis of metabolism and aging in the experimental literature.

There is no product associated with this page.