Promising Level C · preliminary human evidence
NR
NAD+ precursor
Mechanism
Nicotinamide riboside is a precursor the body can use on the pathway toward NAD+.
Research summary
Trials in adults have observed increases in blood NAD+ and acceptable short-term tolerability.
Human evidence
That is biomarker evidence, not longevity evidence. It remains unknown whether the change translates into more healthspan.
Safety
This is not a treatment. Anyone who is pregnant, nursing, underage, or taking medication should consult a professional before using a supplement.
References
- Therapeutic Potential of NAD-Boosting Molecules: The In Vivo EvidenceRajman L, Chwalek K, Sinclair DA. Cell Metabolism, 2018.DOI 10.1016/j.cmet.2018.02.011Reviews the role of NAD+ and of molecules that raise it. The lifespan extension it cites comes mostly from animal models.
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