Early research Level C · preliminary human evidence
Resveratrol
Polyphenols
Mechanism
It was investigated for its relationship with cellular-stress pathways and sirtuins. Human results are mixed.
Research summary
The early expectation was larger than the later clinical evidence.
Human evidence
There is no solid basis for calling it a compound that lengthens life.
Safety
This is not a treatment. Anyone who is pregnant, nursing, underage, or taking medication should consult a professional before using a supplement.
References
- NAD+ and sirtuins in aging and diseaseImai S, Guarente L. Trends in Cell Biology, 2014.DOI 10.1016/j.tcb.2014.04.002Describes NAD+ and sirtuins as an axis of metabolism and aging in the experimental literature.
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